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Baseline Hepatitis C Virus NS5A Resistance-Associated Polymorphisms in Patients With and Without Human Immunodeficiency Virus Coinfection in Mexico
Microbial Drug Resistance ( IF 2.6 ) Pub Date : 2021-09-09 , DOI: 10.1089/mdr.2020.0436
Bruno Ali Lopez Luis 1 , Luis Angulo-Medina 1 , Roberto Rodriguez-Diaz 1 , Luis Enrique Soto-Ramírez 1
Affiliation  

Objective: We aimed to evaluate the frequency and associated factors of baseline NS5A resistance-associated substitutions (RASs) in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) monoinfection with genotype 1b (GT1b) or genotype 1a (GT1a). Moreover, we performed a phylogenetic analysis to evaluate the pattern of clustering among samples of patients with RASs.

中文翻译:

墨西哥有和无人类免疫缺陷病毒合并感染患者的基线丙型肝炎病毒 NS5A 耐药相关多态性

目的:我们旨在评估基因型 1b (GT1b) 或基因型 1a (GT1a) 合并感染人类免疫缺陷病毒 (HIV) 和丙型肝炎病毒 (HCV) 单一感染患者基线 NS5A 耐药相关替代 (RAS) 的频率和相关因素)。此外,我们进行了系统发育分析,以评估 RAS 患者样本之间的聚类模式。
更新日期:2021-09-15
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