Abstract

From the lichen Parmotrema praesorediosum, one new diphenyl peroxide, named praesordin A (1), together with four depsidones, including virensic acid (2), protocetraric acid (3), 8'-O-methylprotocetraric acid (4), and furfuric acid (5) were purified. Their structures were chacracterized using extensive HR-ESI-MS and NMR spectroscopic methods. The isolated compounds (2-5) possessed stronger α-glucosidase inhibitory activity (IC₅₀ = 43.7-110.1 μM) than the standard drug acarbose (IC₅₀ = 214.5 μM).

中文翻译：

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Paresordin A，一种来自地衣 Parmotrema praesorediosum 的新型二苯基环状过氧化物

摘要

来自地衣 Parmotrema praesorediosum 的一种新的过氧化二苯，命名为 praesordin A (1)，以及四种 depsidones，包括 virensic acid ( 2 )、protocetraric acid ( 3 )、8'- O -methylprotocetraric acid ( 4 ) 和糠酸( 5 )纯化。使用广泛的 HR-ESI-MS 和 NMR 光谱方法对它们的结构进行了表征。分离得到的化合物( 2-5 )具有比标准药物阿卡波糖(IC ₅₀ = 214.5 μM)更强的α-葡萄糖苷酶抑制活性(IC _{50 = 43.7-110.1 μM)。}