Imperative introduction of biosensor in the field of medicine, defence, food safety, security and environmental contamination detection acquired paramount attraction. Thus the foundation of the fame of biosensors in detecting wide scope of biomolecules in innumerable fields has driven researchers in advancement of biosensor and enhancing more updates in devices. Among all semiconductor-FET based biosensors grab attraction due to their miniaturization, mass production, ultra-sensitive in nature, improved lifetime, rapid response and reduce thermal budgets. In this review, field effect based biosensors sensitive to ions their principle model along with pros and cons of different structures. Various performance characteristics for semiconductor based biosensor are explored along with detection of label free analytes such as tuberculosis, glucose, antigen 85-B with ISFET. Following with comprehensive detail on MOSFET junction less Silicon based Dual Gate Biosensor with their design parameters for biosensing of neutral and charged analytes with results summarized in table. Drawbacks of dual gate structure introduce cylindrical structures summarized in table with device parameters and respective sensitivity. Role of analytes size in choosing the cavity width and position of analytes influence the sensitivity is recorded. Recent advancement on selectivity, sensitivity and switching results the gate and channel engineering thus compound semiconductor came in picture. In last section challenges with solution and importance of III-V compound channel as scope in biosensor with taking the benefits of fabrication of III-V compound MOSFETs. Semiconductor compound properties are summarized in table for various applications in recent use.

中文翻译：

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基于纳米晶体管的生物传感器的综合分析：综述

迫切需要在医学，国防，食品安全，安全和环境污染检测领域引入生物传感器。因此，生物传感器在众多领域检测广泛的生物分子的名声奠定了基础，推动了研究人员推动生物传感器的发展并增强设备的更多更新。在所有基于半导体FET的生物传感器中，由于其小型化，批量生产，本质上超灵敏，使用寿命长，响应速度快和减少热预算而吸引了人们的注意。在这篇综述中，基于场效应的对离子敏感的生物传感器的原理模型以及不同结构的利弊。探索了基于半导体的生物传感器的各种性能特征，并检测了无标记的分析物，例如结核病，葡萄糖，带有ISFET的抗原85-B。下面详细介绍了MOSFET结较少的硅双门生物传感器及其用于中性和带电分析物生物传感的设计参数，结果汇总在表中。双闸门结构的缺点引入了表中汇总的圆柱结构，以及器件参数和相应的灵敏度。记录分析物大小在选择腔体宽度和分析物位置影响灵敏度方面的作用。选择性，灵敏度和开关方面的最新进展使栅极和通道工程得以实现，从而使复合半导体成为可能。在上一节中，利用III-V复合MOSFET的制造优势，将III-V复合通道作为生物传感器的解决方案和重要性提出了挑战。