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Diffusion property and functional connectivity of superior longitudinal fasciculus underpin human metacognition
Neuropsychologia ( IF 2.6 ) Pub Date : 2021-04-01 , DOI: 10.1016/j.neuropsychologia.2021.107847
Yunxuan Zheng 1 , Danni Wang 2 , Qun Ye 3 , Futing Zou 4 , Yao Li 2 , Sze Chai Kwok 5
Affiliation  

Metacognition as the capacity of monitoring one's own cognition operates across domains. Here, we addressed whether metacognition in different cognitive domains rely on common or distinct neural substrates with combined diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) techniques. After acquiring DTI and resting-state fMRI data, we asked participants to perform a temporal-order memory task and a perceptual discrimination task, followed by trial-specific confidence judgments. DTI analysis revealed that the structural integrity (indexed by fractional anisotropy) in the anterior portion of right superior longitudinal fasciculus (SLF) was associated with both perceptual and mnemonic metacognitive abilities. Using perturbed mnemonic metacognitive scores produced by inhibiting the precuneus using TMS, the mnemonic metacognition scores did not correlate with individuals' SLF structural integrity anymore, revealing the relevance of this tract in memory metacognition. To further verify the involvement of several cortical regions connected by SLF, we took the TMS-targeted precuneus region as a seed in a functional connectivity analysis and found the functional connectivity between precuneus and two SLF-connected regions (inferior parietal cortex and precentral gyrus) mediated mnemonic metacognition performance. These results illustrate the importance of SLF and a putative white-matter grey-matter circuitry that supports human metacognition.



中文翻译:

上纵筋膜的扩散特性和功能连接性是人类元认知的基础

元认知是监视自己的认知的能力,跨领域运作。在这里,我们讨论了在不同认知域中的元认知是否依赖于具有扩散张量成像(DTI)和功能磁共振成像(fMRI)技术的共同或不同的神经基质。在获取DTI和静止状态fMRI数据后,我们要求参与者执行时间顺序记忆任务和知觉辨别任务,然后进行特定于试验的置信度判断。DTI分析显示,右上纵筋膜(SLF)前部的结构完整性(由分数各向异性指示)与知觉和记忆记忆的元认知能力有关。使用通过使用TMS抑制早孕产生的扰动的助记符元认知评分,记忆性元认知评分不再与个体的SLF结构完整性相关,这揭示了该记忆记忆元在记忆元认知中的相关性。为了进一步验证由SLF连接的几个皮质区域的参与,我们将以TMS为靶点的前突神经区域作为功能连通性分析的种子,并发现了前突神经与两个SLF连接区域(下顶叶皮层和中央前回)之间的功能连通性介导的记忆元认知能力。这些结果说明了SLF和支持人类元认知的假定的白底灰阶电路的重要性。为了进一步验证由SLF连接的几个皮质区域的参与,我们将以TMS为靶点的前突神经区域作为功能连通性分析的种子,并发现了前突神经与两个SLF连通区域(下顶叶皮层和中央前回)之间的功能连通性介导的记忆元认知能力。这些结果说明了SLF和支持人类元认知的假定的白底灰阶电路的重要性。为了进一步验证由SLF连接的几个皮质区域的参与,我们将以TMS为靶点的前突神经区域作为功能连通性分析的种子,并发现了前突神经与两个SLF连通区域(下顶叶皮层和中央前回)之间的功能连通性介导的记忆元认知能力。这些结果说明了SLF和支持人类元认知的假定的白底灰阶电路的重要性。

更新日期:2021-04-12
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