Abstract

The mesomorphic properties of linear shaped homologous series based on two linkage group have been designed and synthesized with different side chain substituents (-OR) on the one end of terminal side with presence of lateral nitro group and second terminal iodo substituted group. Novel series consists thirteen members (C₁ to C_8, C₁₀, C₁₂, C₁₄, C₁₆, C₁₈). Compounds (C₁ to C₆) showed nonliquid crystalline properties while compound (C₇ to C₁₈) displayed smectic and nematogenic mesophase properties. The textures of smectic C and nematic phase are fan, schlieren and droplets type. All these compounds were characterized by spectroscopic techniques such as [FTIR] and ¹H Nuclear magnetic resonance [NMR] spectroscopy. The mesomorphic properties of these compounds were observed by POM and further confirmed by DSC and XRD. Chalconyl ester based compounds (C₃ to C₁₂) shows good antibacterial as well as antifungal activity compared with corresponding standard drugs.

摘要

设计并合成了基于两个连接基团的线形同源系列的介晶性质，在末端一侧有不同的侧链取代基 (-OR)，存在侧向硝基和第二个末端碘取代基团。小说系列由十三名成员（C ₁至C _8、 C ₁₀、C ₁₂、C ₁₄、C ₁₆、C ₁₈）组成。化合物（C ₁至 C ₆）表现出非液晶性质，而化合物（C ₇至 C ₁₈) 显示近晶和致线虫中间相特性。近晶C和向列相的织构为扇形、纹影和液滴型。所有这些化合物都通过光谱技术表征，例如 [FTIR] 和¹ H 核磁共振 [NMR] 光谱。这些化合物的介晶性质通过 POM 观察并通过 DSC 和 XRD 进一步证实。与相应的标准药物相比，基于查尔酮酯的化合物（C ₃至 C ₁₂）显示出良好的抗菌和抗真菌活性。