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Sex differences in re-experiencing symptoms between husbands and wives who lost their only child in China: a resting-state functional connectivity study of hippocampal subfields
Frontiers in Human Neuroscience ( IF 2.9 ) Pub Date : 2021-04-01 , DOI: 10.3389/fnhum.2021.655044 Yifeng Luo , Yu Liu , Zhao Qing , Li Zhang , Yifei Weng , Xiaojie Zhang , Hairong Shan , Lingjiang Li , Rongfeng Qi , Zhihong Cao , Guangming Lu
Frontiers in Human Neuroscience ( IF 2.9 ) Pub Date : 2021-04-01 , DOI: 10.3389/fnhum.2021.655044 Yifeng Luo , Yu Liu , Zhao Qing , Li Zhang , Yifei Weng , Xiaojie Zhang , Hairong Shan , Lingjiang Li , Rongfeng Qi , Zhihong Cao , Guangming Lu
Background: Losing one’s only child may lead to posttraumatic stress disorder (PTSD), of which re-experiencing is the core symptom. However, neuroimaging studies of sex differences in re-experiencing in the context of the trauma of losing one’s only child and PTSD are scarce; comparisons of the functional networks from the hippocampal subfields to the thalamus might clarify the neural basis. Methods: Thirty couples without any psychiatric disorder who lost their only child (non-PTSD group), 55 patients with PTSD, and 50 normal controls underwent resting-state functional magnetic resonance imaging. The functional connectivity (FC) from the hippocampal subregions to the thalamus and the correlations of FC with re-experiencing symptoms were analyzed within and between the sexes. Results: Compared with husbands without PTSD, wives without PTSD had higher re-experiencing symptoms and weaker FC between the right hippocampal cornu ammonis 3 (RCA3) and the right thalamus (RT; RCA3-RT). Moreover, only the correlation between the RCA3-RT FC and re-experiencing in wives without PTSD was significant. Among the three groups, only the RCA3-RT FC in female subjects was markedly different. Additionally, the RCA3-RT FC in wives without PTSD was remarkably lower relative to female patients with PTSD. Conclusions: Wives without PTSD who lost their only child had worse re-experiencing symptoms relative to their husbands, which was associated with the FC alteration between the hippocampal subregions and the thalamus. Importantly, the low level of the RCA3-RT FC may play a potentially protective role against the development of PTSD in wives who have lost their only child.
更新日期：2021-04-01
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