Background:

Older breast cancer survivors are at an increased risk of loss of postural balance and accidental falls, however, the ability of clinical mobility measures to predict falls has not been determined. The purpose of this study was to examine the prognostic ability, sensitivity, and specificity to predict accidental falls in measures of gait speed and functional mobility in older breast cancer survivors.

Methods:

Thirty-four breast cancer survivors 65 years and older performed 3 measures of gait speed (GS) (usual, fast, dual-task) and Timed Up and Go (TUG) (TUG, TUG-Cognitive, TUG-Manual). Follow-up calls were made 3 months after testing to track falls.

Results:

The area under the curve (AUC) was below 0.5 for all GS measures, indicating poor predictive ability and all GS measures had low sensitivity and specificity to predict falls. All TUG measures had AUC values above 0.5. The cutoff score with the best sensitivity/specificity to predict falls was: TUG-Cognitive = 11.32 seconds, Sens = 0.64, Spec = 0.80; TUG-Manual = 9.84 seconds, Sens = 0.71, Spec = 0.65.

Conclusion:

When assessing fall risk in older breast cancer survivors, performance on the TUG and TUG-Cognitive are able to predict falls.

中文翻译：

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评估步态速度和定时起跳测量作为老年乳腺癌幸存者跌倒的预测指标

背景：

老年乳腺癌幸存者失去姿势平衡和意外跌倒的风险增加，但是，尚未确定临床移动性措施预测跌倒的能力。本研究的目的是检查预测老年乳腺癌幸存者步态速度和功能活动能力意外跌倒的预后能力、敏感性和特异性。

方法：

34 名 65 岁及以上的乳腺癌幸存者进行了 3 项步态速度 (GS)（通常、快速、双任务）和定时起身 (TUG)（TUG、TUG-Cognitive、TUG-Manual）测量。在测试后 3 个月进行了后续电话跟踪以跟踪跌倒。

结果：

所有 GS 测量的曲线下面积 (AUC) 均低于 0.5，表明预测能力较差，并且所有 GS 测量对预测跌倒的敏感性和特异性较低。所有 TUG 测量的 AUC 值都高于 0.5。预测跌倒的最佳敏感性/特异性的截止分数是：TUG-Cognitive = 11.32 秒，Sens = 0.64，Spec = 0.80；TUG-Manual = 9.84 秒，Sens = 0.71，Spec = 0.65。

结论：

在评估老年乳腺癌幸存者的跌倒风险时，TUG 和 TUG-Cognitive 的表现能够预测跌倒。