Abstract

Background

Promoting brain health depends on sustaining healthy behaviors across the lifespan. Yet, public adoption of lifestyle behaviors and knowledge of cognitive decline (CD) prevention remains poor. Our multidisciplinary team developed My Healthy Brain (MHB) to promote a healthy lifestyle (e.g. diet, exercise, alcohol, sleep) and build cognitive reserve (e.g. memory compensatory strategies). Our objective was to demonstrate early proof-of-concept for MHB by exploring the feasibility, acceptability, and improvement in primary lifestyle outcomes as well as secondary outcomes of self-determination and subjective wellbeing.

Materials and Methods

Older adults with subjective (self-report only) or objective (confirmed by cognitive testing) CD, referred by neurologists to modify lifestyle risk factors (e.g. sedentary), participated in a non-randomized open pilot of MHB (N = 24). Participants completed the 8-week MHB group (90 min each) and pre-post outcome measures.

Results

MHB met all a-priori set benchmarks, including good feasibility of recruitment (71% of patients screened) and enrollment (75% completed baseline), and good acceptability of treatment (75% completed 6 of 8 sessions and post-testing). Program satisfaction was excellent (100% of participants) and no adverse events were reported. We also observed improvements in primary lifestyle outcomes as well as secondary outcomes of self-determination and subjective well-being.

Discussion

While MHB demonstrated preliminary feasibility and the potential to modify lifestyle risk factors for CD, the program can be improved. Future work will explore the integration of mindfulness skills with behavioral principles to bolster multidomain lifestyle change, and the live video delivery format to bypass barriers to participation.

中文翻译：

---

我的健康大脑：促进大脑健康的多模式生活方式计划

摘要

背景

促进大脑健康取决于在整个生命周期中保持健康的行为。然而，公众对生活方式行为的采纳和认知衰退 (CD) 预防知识仍然很薄弱。我们的多学科团队开发了我的健康大脑(MHB)，以促进健康的生活方式（例如饮食、锻炼、饮酒、睡眠）并建立认知储备（例如记忆补偿策略）。我们的目标是通过探索主要生活方式结果以及自决和主观幸福感的次要结果的可行性、可接受性和改善来证明 MHB 的早期概念验证。

材料和方法

患有主观（仅自我报告）或客观（通过认知测试确认）CD 的老年人，由神经科医生推荐以改变生活方式风险因素（例如久坐不动），参加了 MHB 的非随机开放试点（N  = 24）。参与者完成了为期 8 周的 MHB 组（每组 90 分钟）和事后结果测量。

结果

MHB 符合所有先验设定的基准，包括良好的招募可行性（71% 的患者筛查）和入组（75% 完成基线），以及良好的治疗可接受性（75% 完成 8 个疗程中的 6 个和后测试）。项目满意度非常好（100% 的参与者）并且没有报告任何不良事件。我们还观察到主要生活方式结果以及自决和主观幸福感的次要结果的改善。

讨论

虽然 MHB 展示了初步的可行性和改变 CD 生活方式风险因素的潜力，但该计划可以改进。未来的工作将探索正念技能与行为原则的整合，以支持多领域生活方式的改变，以及绕过参与障碍的实时视频交付格式。