Natural products play an important role in various drug discovery and development approaches. They are known to be the rich resources for the identification of new chemical entities (NCEs) intended to treat various diseases. Many drugs have been discovered and developed from natural sources. Indeed, collaborative efforts involving biologists as well as organic, medicinal, and phytochemists usually facilitate the identification of potent NCEs derived from natural sources. Over the past 20 years, more than 50% of NCEs have been derived either from marine sources or synthetic/ semisynthetic derivatives of natural products. Indeed, many drug molecules have been designed by considering natural products as the starting scaffold. The first bis-pyrrole alkaloid derivative of marinopyrroles was obtained from the marine-derived streptomycete species. In the laboratory, it can be synthesized via Clauson-Kaas and Friedel-Crafts arylation as well as copper-mediated N-arylation process under microwave irradiation. The marinopyrrole A (±)-28 was discovered to overcome resistance against human cancer cells by antagonizing B-cell lymphoma extra-large (Bcl-xL) and induced myeloid leukaemia cell (Mcl-1). In this review, we elaborated on various synthetic pathways of marinopyrroles possessing anti-cancer potential, which could encourage researchers to discover promising anti-tumor agents.

天然产物在各种药物发现和开发方法中起着重要作用。众所周知，它们是用于鉴定旨在治疗各种疾病的新化学实体（NCE）的丰富资源。已经从自然资源中发现和开发了许多药物。确实，生物学家以及有机，药物和植物化学家的共同努力通常有助于鉴定源自自然资源的有效NCE。在过去的20年中，超过50％的NCE来自海洋资源或天然产物的合成/半合成衍生物。实际上，已经通过将天然产物视为起始支架来设计了许多药物分子。marinopyrroles的第一个双吡咯生物碱衍生物是从海洋衍生的链霉菌种获得的。在实验室中，它可以通过Clauson-Kaas和Friedel-Crafts芳基化以及在微波辐射下铜介导的N-芳基化过程合成。发现马诺吡咯A（±）-28通过拮抗超大型B细胞淋巴瘤（Bcl-xL）和诱导髓样白血病细胞（Mcl-1）来克服对人类癌细胞的抗性。在这篇综述中，我们详细阐述了具有抗癌潜力的marinopyrroles的各种合成途径，这可能会鼓励研究人员发现有前途的抗肿瘤药。发现马诺吡咯A（±）-28通过拮抗超大型B细胞淋巴瘤（Bcl-xL）和诱导髓样白血病细胞（Mcl-1）来克服对人类癌细胞的抗性。在这篇综述中，我们详细阐述了具有抗癌潜力的marinopyrroles的各种合成途径，这可能会鼓励研究人员发现有前途的抗肿瘤药。发现马诺吡咯A（±）-28通过拮抗超大型B细胞淋巴瘤（Bcl-xL）和诱导髓样白血病细胞（Mcl-1）来克服对人类癌细胞的抗性。在这篇综述中，我们详细阐述了具有抗癌潜力的marinopyrroles的各种合成途径，这可能会鼓励研究人员发现有前途的抗肿瘤药。