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Chemical Constituents and Antibacterial Activity of Cissus aralioides
Letters in Organic Chemistry ( IF 0.8 ) Pub Date : 2021-03-31 , DOI: 10.2174/1570178617999200609130127
Balogun Olaoye Solomon 1 , Ajayi Olukayode Solomon 1 , Owolabi Temitayo Abidemi 1 , Oladimeji Abdulkabir Oladele 2 , Liu Zhiqiang 3
Affiliation  

Cissus aralioides is a medicinal plant used in sub-Saharan Africa for the treatment of infectious diseases; however, the chemical constituents of the plant have not been investigated. Thus, in this study, an attempt was made at identifying predominant phytochemical constituents of the plant through chromatographic purification and silylation of the plant extract, and subsequent characterization using spectroscopic and GC-MS techniques. The minimum inhibitory concentration (MICs) for the antibacterial activities of the plant extract, chromatographic fractions, and isolated compounds were also examined. Chromatographic purification of the ethyl acetate fraction from the whole plant afforded three compounds: β-sitosterol (1), stigmasterol (2), and friedelin (3). The phytosterols (1 and 2) were obtained together as a mixture. The GC-MS analysis of silylated extract indicated alcohols, fatty acids, and sugars as predominant classes, with a composition of 24.62, 36.90 and 26.52%, respectively. Results of MICs indicated that friedelin and other chromatographic fractions had values (0.0626-1.0 mg/mL) comparable with the standard antibiotics used. Characterization of natural products from C. aralioides is being reported for the first time in this study.



中文翻译:

顺毛化学成分和抗菌活性

Cissus aralioides是一种在撒哈拉以南非洲用于治疗传染病的药用植物;但是,尚未对该植物的化学成分进行调查。因此,在这项研究中,人们尝试通过色谱纯化和甲硅烷基化提取植物提取物,然后通过光谱和GC-MS技术鉴定植物的主要植物化学成分。还检查了植物提取物,色谱级分和分离出的化合物的抗菌活性的最小抑菌浓度(MICs)。从整个植物中色谱纯化乙酸乙酯部分,得到了三种化合物:β-谷甾醇(1),豆甾醇(2)和弗瑞德林(3)。一起获得了植物甾醇(1和2)的混合物。甲硅烷基化提取物的GC-MS分析表明,醇,脂肪酸和糖为主要类别,组成分别为24.62%,36.90%和26.52%。MIC的结果表明,弗瑞德林和其他色谱级分的值(0.0626-1.0 mg / mL)与所用的标准抗生素相当。这项研究中首次报道了来自阿拉伯衣藻的天然产物的表征。

更新日期:2021-03-31
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