1-Butyl-3-methylimidazolium hydrogen sulfate [bmim]HSO₄ as a non-halogenated ionic liquid was loaded on graphene oxide ([bmim]HSO₄/GO) and employed as a green, reusable, solid nanocatalyst for the preparation of polysubstituted pyrroles in the presence of amines (such as benzeneamine, 2-amino-4-methylthiazole, adenine (9H-purin-6-amine)), benzaldehydes or cinnamaldehyde or furfural, 1,3-dicarbonyl compounds, and nitromethane at 90-95°C. The advantages of this protocol are the synthesis of some novel polysubstituted pyrroles containing fluorine atoms, thiazole and adenine nuclei that are very important in pharmaceutical and drug discovery research in comparison to previously reported results.

将作为非卤代离子液体的1-丁基-3-甲基咪唑硫酸氢盐[bmim] HSO ₄负载在氧化石墨烯（[bmim] HSO ₄ / GO）上，并用作绿色，可重复使用的固体纳米催化剂，用于制备多取代的胺（例如苯胺，2-氨基-4-甲基噻唑，腺嘌呤（9H-嘌呤-6-胺），苯甲醛或肉桂醛或糠醛，1,3-二羰基化合物和硝基甲烷在90-95下存在下的吡咯℃。该方案的优点是合成了一些新颖的含氟原子，噻唑和腺嘌呤核的多取代吡咯，与以前报道的结果相比，它们在药物和药物发现研究中非常重要。