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Synthesis of 4,6-Dimethylpyrimidine 2-Thiosubstituted Derivatives and Their Preliminary Biological Evaluation
Letters in Organic Chemistry ( IF 0.8 ) Pub Date : 2021-03-31 , DOI: 10.2174/1570178617999200601165334
Aleksandr P. Yengoyan 1 , Elen N. Hambardzumyan 2 , Asya S. Vorskanyan 2 , Lusya V. Shahba-Zyan 2
Affiliation  

Based on 4,6-dimethylpyrimidine-2-thiol hydrochloride a series of its novel S-substituted derivatives including bi- and tricyclic heterosystems with a combination of azines and pyrazole cycles in the molecule were synthesized. The preliminary biological screening has shown that the obtained compounds have a pronounced plants growth-stimulating activity, which is a new property for these heterosystems. This fact indicates the prospectivity of further development of synthesized systems for the search for new plants growth stimulators.



中文翻译:

4,6-二甲基嘧啶2-硫取代的衍生物的合成及其初步生物学评价

基于4,6-二甲基嘧啶-2-硫醇盐酸盐,合成了一系列新型的S取代衍生物,包括双环和三环杂原子系统,并且在分子中结合了嗪和吡唑环。初步的生物学筛选表明,所获得的化合物具有显着的植物生长刺激活性,这是这些异源系统的新特性。这一事实表明进一步开发合成系统以寻找新的植物生长刺激剂的前景。

更新日期:2021-03-31
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