An efficient, green and rapid protocol for one-pot synthesis of substituted imidazoles from isatin, aryl/hetero-aryl aldehydes and ammonium acetate in presence of CuO-TiO₂-GO nanocomposite as catalyst under microwave irradiation has been reported in this article. The CuO-TiO₂-GO nanocomposite was synthesized by the hydrothermal method. Further, the prepared composite was characterized by FT-IR, XRD, FESEM, EDS, TEM, Raman and TGA techniques. The protocol offered several advantages such as high rate of reaction, excellent yields, economic feasibility, simple work-up and reusability of catalyst up to six cycles. Further antimicrobial activities of the synthesized substituted imidazoles were evaluated by the broth dilution method.

本文报道了在微波辐射下，在CuO-TiO ₂ -GO纳米复合材料作为催化剂的情况下，由靛红，芳基/杂芳基醛和乙酸铵一锅法合成高效，绿色，快速的方案，可从靛红，芳基/杂芳基醛和乙酸铵进行一锅合成。采用水热法合成了CuO-TiO ₂ -GO纳米复合材料。此外，通过FT-IR，XRD，FESEM，EDS，TEM，拉曼和TGA技术对制备的复合材料进行表征。该方案具有许多优点，例如反应速率高，产率高，经济可行性，后处理简单以及催化剂可重复使用多达六个循环。通过肉汤稀释法评价合成的取代的咪唑的其他抗菌活性。