Binding behaviours between cyclopentanocucurbit[6]uril (CyP₆Q[6]) and three amino acids have been investigated by means of X-ray crystallography, proton nuclear magnetic resonance spectroscopy and isothermal titration calorimetry. The results showed that CyP₆Q[6] forms a 1 : 2 inclusion complex with glycine, but 1 : 1 complexes with both leucine and lysine. Whereas the carboxyl group of glycine can enter the interior of the cavity of CyP₆Q[6], only the alkyl chains of leucine and lysine can enter this cavity. Interestingly, leucine can adopt two different self-assembly modes upon its interaction with cucurbituril, depending on the external conditions, whereas glycine and lysine do not exhibit such behaviour.

X射线晶体学，质子核磁共振波谱和等温滴定热法研究了环戊anocurcurbit [6]尿嘧啶（CyP ₆ Q [6]）和三个氨基酸之间的结合行为。结果表明，CyP ₆ Q [6]与甘氨酸形成1：2的包合物，但与亮氨酸和赖氨酸成1：1的包合物。甘氨酸的羧基可以进入CyP ₆ Q [6]的空腔内部，而只有亮氨酸和赖氨酸的烷基链可以进入该空腔。有趣的是，亮氨酸在与葫芦素相互作用时可以采用两种不同的自组装模式，这取决于外部条件，而甘氨酸和赖氨酸则不表现出这种行为。