Regulating the catalytic activity of nanozymes is significant for their applications in various fields. Here, we demonstrate a new strategy to achieve reversible regulation of the nanozyme's activity for sensing purpose. This strategy involves the use of zero-dimensional MoS₂ quantum dots (MQDs) as the building blocks of nanozymes which display very weak peroxidase (POD)-like activity. Interestingly, such POD-like activity of the MQDs largely enhances in the presence of Fe³⁺ while diminishes with the addition of captopril thereafter. Further investigations identify the mechanism of Fe³⁺-mediated aggregation-induced enhancement of the POD-like activity and the inhibitory effect of captopril on the enhancement, which is highly dependent on their concentrations. Based on this finding, a colorimetric method for the detection of captopril is developed. This sensing approach exhibits the merits of simplicity, rapidness, reliability, and low cost, which has been successfully applied in quality control of captopril in pharmaceutical products. Moreover, the present sensing platform allows smartphone read-out, which has promising applications in point-of-care testing devices for clinical diagnosis and drug analysis.

调控纳米酶的催化活性对其在各个领域的应用具有重要意义。在这里，我们展示了一种新的策略来实现纳米酶活性的可逆调节以达到传感目的。该策略涉及使用零维 MoS ₂量子点 (MQD) 作为纳米酶的构建块，纳米酶表现出非常弱的过氧化物酶 (POD) 样活性。有趣的是，MQDs 的这种 POD 样活性在 Fe ³⁺存在下大大增强，而随后随着卡托普利的添加而降低。进一步研究确定了 Fe ^3+的机理介导的聚集诱导的 POD 样活性增强和卡托普利对增强的抑制作用，这高度依赖于它们的浓度。基于这一发现，开发了一种检测卡托普利的比色法。这种传感方法具有简单、快速、可靠、成本低等优点，已成功应用于医药产品中卡托普利的质量控制。此外，目前的传感平台允许智能手机读取，这在临床诊断和药物分析的即时检测设备中具有广阔的应用前景。