In this study, we evaluated the biosafety of a novel polyetheretherketone (PEEK) copolymer [P(E2-E4)K] composite using an animal model to test an implanted orthopedic spine cage. The PEEK copolymer was synthesized by solution polymerization with diphenyl sulfone solvent and blended with carbon fibers and graphene oxide to produce the composite. The P(E2-E4)K composite exhibited improved mechanical properties, similar to natural bone. The animal study results for short-term inflammation evaluation by hematoxylin & eosin and immunostaining methods showed significant histochemical stability for 3 weeks after implantation, demonstrating the required biosafety for medical application as an implantable spine cage.

在这项研究中，我们使用动物模型评估了植入的矫形脊柱笼，评估了新型聚醚醚酮（PEEK）共聚物[P（E2-E4）K]复合物的生物安全性。通过与二苯砜溶剂进行溶液聚合来合成PEEK共聚物，然后将其与碳纤维和氧化石墨烯共混以生产复合材料。P（E2-E4）K复合材料表现出改善的机械性能，类似于天然骨。通过苏木精和曙红和免疫染色方法进行的短期炎症评估的动物研究结果显示，植入后3周内组织化学稳定性显着，证明了医疗应用作为可植入脊柱笼所需的生物安全性。