Nanobubbles (NBs) have recently garnered widespread attention for their potential use as dual diagnostic and therapeutic agents. Similar to their micron-sized relatives (microbubbles), NBs are shell-stabilized, gas-cored bubbles that in conjunction with ultrasound can be used to increase imaging contrast, as well as provide a mechanism for trigger drug release and increased therapeutic delivery.

In this review, we specifically focus on their development as agents to enhance drug delivery, discussing theory, characterization techniques, key formulations and prospects for translation into clinical use.

中文翻译：

---

用于治疗的纳米气泡：生产，稳定性和当前前景

纳米气泡（NBs）由于其潜在的双重诊断和治疗作用而受到了广泛的关注。类似于它们的微米级亲戚（微气泡），NB是壳稳定的，带有气泡的气泡，可与超声结合使用以增加成像对比度，并提供触发药物释放和增加治疗递送的机制。

在这篇综述中，我们特别关注它们作为增强药物递送的药物的发展，讨论理论，表征技术，关键制剂以及将其转化为临床用途的前景。