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Computerized Cognitive Training in Amnestic Mild Cognitive Impairment: A Randomized Clinical Trial
Journal of Geriatric Psychiatry and Neurology ( IF 2.6 ) Pub Date : 2021-03-30 , DOI: 10.1177/08919887211006472
Kevin Duff 1 , Jian Ying 2 , Kayla R Suhrie 1 , Bonnie C A Dalley 1 , Taylor J Atkinson 1, 3 , Sariah M Porter 1 , Ava M Dixon 1 , Dustin B Hammers 1 , Fredric D Wolinsky 4
Affiliation  

Objective:

Computerized cognitive training has been successful in healthy older adults, but its efficacy has been mixed in patients with amnestic Mild Cognitive Impairment (MCI).

Methods:

In a randomized, placebo-controlled, double-blind, parallel clinical trial, we examined the short- and long-term efficacy of a brain-plasticity computerized cognitive training in 113 participants with amnestic MCI.

Results:

Immediately after 40-hours of training, participants in the active control group who played computer games performed better than those in the experimental group on the primary cognitive outcome (p = 0.02), which was an auditory memory/attention composite score. There were no group differences on 2 secondary outcomes (global cognitive composite and rating of daily functioning). After 1 year, there was no difference between the 2 groups on primary or secondary outcomes. No adverse events were noted.

Conclusions:

Although the experimental cognitive training program did not improve outcomes in those with MCI, the short-term effects of the control group should not be dismissed, which may alter treatment recommendations for these patients.



中文翻译:

遗忘性轻度认知障碍的计算机化认知训练:一项随机临床试验

客观的:

计算机化认知训练在健康的老年人中取得了成功,但其在患有遗忘性轻度认知障碍 (MCI) 的患者中的疗效参差不齐。

方法:

在一项随机、安慰剂对照、双盲、平行的临床试验中,我们在 113 名患有遗忘性 MCI 的参与者中检查了大脑可塑性计算机化认知训练的短期和长期疗效。

结果:

在 40 小时的训练之后,玩电脑游戏的主动控制组的参与者在主要认知结果(p = 0.02)上的表现优于实验组,这是一个听觉记忆/注意力综合评分。2 个次要结果(整体认知综合和日常功能评分)没有组间差异。1 年后,两组之间的主要或次要结果没有差异。没有发现不良事件。

结论:

尽管实验性认知训练计划并未改善 MCI 患者的预后,但不应忽视对照组的短期效果,这可能会改变对这些患者的治疗建议。

更新日期:2021-03-30
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