The efficacy of escitalopram in major depressive disorder: a multicenter randomized, placebo-controlled double-blind study.,International Clinical Psychopharmacology

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The efficacy of escitalopram in major depressive disorder: a multicenter randomized, placebo-controlled double-blind study.
International Clinical Psychopharmacology ( IF 2.6 ) Pub Date : 2021-3-30 , DOI: 10.1097/yic.0000000000000350
Xiaoliang Wang ₁ , Yimin Fan ₁ , Guanjun Li ₁ , Huafang Li _{1,

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Affiliation

The aim of the study was to conduct a multicenter randomized double-blinded placebo-controlled clinical study to evaluate the efficacy of a generic form of escitalopram in treating major depressive disorder (MDD). A total of 390 MDD patients admitted to hospitals in six cities in China were randomized to receive the generic version of escitalopram, the proprietary form of escitalopram (Lexapro) or placebo. During the 8-week treatment, the Hamilton rating scale for depression-17 (HAM-D17), Hamilton Anxiety Rating Scale (HAMA), Montgomery-Åsberg Depression Rating Scale (MADRS), Clinical Global Impressions scale (CGI), current visual analogue scale pain levels (VAS-P1) and Sheehan Disability Scale (SDS) assessments were performed at week 0, 1, 2, 4, 6 and 8 to evaluate treatment responses. HAM-D17, MADRS, HAMA and CGI-S levels of patients who received escitalopram or Lexapro decreased steadily during 8 weeks' treatment, whereas the placebo group showed a relatively smaller reduction of these levels (P < 0.001). SDS and VAS-P1 both decreased after treatment with generic escitalopram or proprietary escitalopram Lexapro. Our results indicated that both the generic escitalopram and proprietary escitalopram Lexapro had potent efficacy in treating MDD.

更新日期：2021-03-31

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