ABSTRACT

Adolescent survivors of pediatric brain tumor (PBT) are a sparsely studied subset of childhood cancer survivors. Sustaining a PBT may complicate the development of executive functions (EFs), which play a vital role in long-term psychosocial adjustment. In this study, 48 adolescent survivors and their parents completed questionnaires assessing EF, psychological symptoms, fatigue, and adaptive functioning, and 26 survivors underwent neuropsychological assessment. Survivors reported significantly more problems with adaptive functioning than a healthy control group, and this was most strongly associated to executive dysfunction, compared to psychological symptoms and fatigue. The findings have important implications for long-term follow-ups.

摘要

儿童脑肿瘤 (PBT) 的青少年幸存者是儿童癌症幸存者的一个研究稀少的子集。维持 PBT 可能会使执行功能 (EF) 的发展复杂化，而执行功能在长期心理社会调整中起着至关重要的作用。在这项研究中，48 名青少年幸存者及其父母完成了评估 EF、心理症状、疲劳和适应性功能的问卷，26 名幸存者接受了神经心理学评估。幸存者报告的适应性功能问题明显多于健康对照组，与心理症状和疲劳相比，这与执行功能障碍的相关性最强。这些发现对长期随访具有重要意义。