β-arrestin 2 is an intracellular protein recruited during the activation of G-protein-coupled receptors. In preclinical studies, β-arrestin 2 has been implicated in µ-opioid receptor desensitization and internalization and the development of opioid tolerance and dependence. The present study investigated relationships between variants in the gene encoding β-arrestin 2 (ARRB2) and clinically relevant phenotypes among individuals with opioid use disorder (OUD). We hypothesized that ARRB2 variants would be associated with the negative effects of long-term heroin use.

中文翻译：

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β-抑制素 2 (ARRB2) 多态性与长期使用海洛因的不良后果相关

β-抑制蛋白 2 是一种在 G 蛋白偶联受体激活过程中募集的细胞内蛋白。在临床前研究中，β-抑制蛋白 2 与 μ-阿片受体脱敏和内化以及阿片耐受和依赖的发展有关。本研究调查了编码 β-抑制蛋白 2 ( ARRB2 )的基因变异与阿片类药物使用障碍 (OUD) 患者临床相关表型之间的关系。我们假设ARRB2变体与长期使用海洛因的负面影响有关。