Abstract

The objective was to elucidate the effects of dietary guanidinoacetic acid (GAA) supplementation on broiler performance, serum enzymes, oxidative biomarkers, mitochondrial activities, carcase traits, gross lesion of cardiac muscle and liver histopathology in broilers challenged with T₃-hormone. A total-of-192 one-day-old mixed sexed broilers were randomly assigned in a two factorial design, including two dietary treatments; control diet supplemented with or without T₃-hormone (1.5 ppm) and GAA diet (0.06%) supplemented with or without T₃-hormone (1.5 ppm). Each group was subdivided into eight replicates. Results showed interactions between GAAxT₃-hormone. GAA diet significantly mitigated the negative effect of T₃-hormone on serum total creatine kinase (CK), cardiac muscle (CK-MB), liver malondialdehyde (MDA) and superoxide dismutase (SOD), mitochondrial activities of cardiac muscle and liver histopathological lesion. In conclusion, GAA at a rate of 0.06% may have the potential to mitigate the negative effect of dietary T₃-hormone but could not reduce the ascites mortality at such inclusion rate.

• HIGHLIGHTS

• GAA protected heart muscle.

• GAA mitigated the oxidative radicals in T₃-hormone challenged birds.

• GAA modulated the mitochondrial activities in T₃-hormone challenged birds.

摘要

目的是阐明日粮胍基乙酸（GAA）补充对受T ₃激素攻击的肉鸡的肉鸡生产性能，血清酶，氧化生物标志物，线粒体活性，car体特征，心肌的总体病变和肝脏组织病理学的影响。总共192个1天大的混合性别肉鸡被随机分配到两个因子设计中，包括两种饮食疗法。控制饮食补充有或不使用T ₃ -hormone（1.5 PPM）和补充有或不使用T GAA饮食（0.06％）₃ -hormone（1.5 ppm）表示。每一组再分为八个重复。结果显示GAAxT _3-激素之间的相互作用。GAA饮食显着减轻了T ₃的负面影响激素对血清总肌酸激酶（CK），心肌（CK-MB），肝丙二醛（MDA）和超氧化物歧化酶（SOD），心肌线粒体活性和肝组织病理病变的影响。总之，以0.06％的比例存在的GAA可能具有减轻饮食中T ₃激素的负面影响的潜力，但不能以这种包含率降低腹水死亡率。

• 强调

• GAA保护了心肌。

• GAA减轻了T ₃激素攻击鸟类的氧化自由基。

• GAA调节了受T ₃激素攻击的鸟类的线粒体活性。