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New mesostructured origami silica matrix: a nano-platform for highly retentive and pH-controlled delivery system
Journal of Taibah University for Science ( IF 3.3 ) Pub Date : 2021-03-29 , DOI: 10.1080/16583655.2021.1902176
Mirza Mahmood Baig 1 , Muhammad Asif Yousuf 1 , Ibrahim A. Alsafari 2, 3 , Muhammad Ali 4 , Philips O. Agboola 5 , Imran Shakir 6 , Sajjad Haider 7 , Muhammad Farooq Warsi 1
Affiliation  

In the present study, stabilizer caged fluorescent rhodamine B mesoporous silica particles with special shapes were prepared. The prepared particles have a pore volume of 1.92 cm3/g and a pore diameter of 12 nm. The abundant hydroxyl functional groups of mesoporous silica are responsible for the superior loading capacity of target molecular specie. The appearance of bands due to –COOH, –CH3, –CH2, –NH etc. indicated that the fluorescent rhodamine B could be encaged with the stabilizer inside the mesoporous channels. The performance of mesostructured origami silica matrix was evaluated by in vitro release experiments. From the in vitro release results, this material is suggested to have appropriate features for almost no release at pH = 1.2 and very slow release at neutral pH value. The same material could be best employed at pH 4.5 and at high pH values. It is concluded that mesostructured origami silica matrix is a smart nano-platform and can be utilized for high retention of cargo molecules.



中文翻译:

新的介观结构的折纸二氧化硅基质:用于高度保持性和pH控制的输送系统的纳米平台

在本研究中,制备了具有特殊形状的稳定剂笼状荧光若丹明B介孔二氧化硅颗粒。制备的颗粒的孔体积为1.92cm 3 / g,孔直径为12nm。介孔二氧化硅的丰富羟基官能团是目标分子物种优异的负载能力的原因。由-COOH,-CH 3,-CH 2,-NH等引起的谱带的出现表明荧光若丹明B可能被介孔通道内的稳定剂所包裹。通过体外释放实验评估了介孔结构的折纸二氧化硅基质的性能。从体外释放结果表明,该材料具有适当的功能,在pH = 1.2时几乎没有释放,而在中性pH值时释放非常慢。在pH 4.5和高pH值下,最好使用相同的材​​料。结论是介观折纸二氧化硅基质是一种智能的纳米平台,可用于货物分子的高度保留。

更新日期:2021-03-30
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