Isoindolinone- and tetrahydroisoquinoline-based cyclic scaffolds comprise the key, structural feature of a wide range of biologically active molecules. Here we report an, approach for the synthesis of chiral isoindolinones and tetrahydroisoquinolines based, on the umpolung allylation of imines. The products contain a free N–H group, which is, primed for further derivatization.

中文翻译：

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亚胺的催化不对称物质催化合成异吲哚啉酮和四氢异喹啉

基于异吲哚啉酮和四氢异喹啉的环状支架包含了广泛的生物活性分子的关键，结构特征。在这里，我们报告了一种基于亚胺的烯丙基烯丙基化来合成手性异吲哚啉酮和四氢异喹啉的方法。产品包含一个自由的NH基团，该基团已准备好进一步衍生化。