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Material Engineering Platform for Next Generation of Neurobiological Interfaces
Accounts of Materials Research ( IF 14.6 ) Pub Date : 2021-03-29 , DOI: 10.1021/accountsmr.0c00103 Siyuan Rao 1 , Jingyi Qiu 1
Accounts of Materials Research ( IF 14.6 ) Pub Date : 2021-03-29 , DOI: 10.1021/accountsmr.0c00103 Siyuan Rao 1 , Jingyi Qiu 1
Affiliation
Made available for a limited time for personal research and study only License. Figure 1. Schematic illustration of two features of the material engineering platform for neurobiological interfaces and the internal relationships among material performance to enable these functions, material properties, materials structures and processing. The two features, the capability to communicate with neural circuits and the compatibility with behavioral outputs, are highlighted. Parts are reproduced with permission from ref (1). Figure 2. Schematic illustration of material structures and processing to enable the compatibility with behavioral observation using wireless control and the multimodalities integration to allow material tools communicating with neural circuits. The control over material structures in nanoscale permits them to work as actuators responding to external stimuli, such as the magnetic field (MF) and near-infrared light (NIR), to modulate neural activity with freely behaving experimental subjects. The technical foundation that allows communication with neuronal cells lies in the integration of multiple modalities within miniaturized material devices. The thermal drawing approaches and the microfabrication processes empower neural probes in optical and electrical stimulation and recording, chemical perturbation and detection, and genetic manipulation. UCNPs: upconversion nanoparticles. Parts are reproduced with permission from ref (1). Copyright 2019 Springer Nature. The authors declare no competing financial interest. The authors declare no competing financial interest.
Siyuan Rao is an Assistant Professor in the Biomedical Engineering Department at the University of Massachusetts Amherst and the principal investigator of the Neurobiological Interfaces Laboratory. She obtained her Bachelor’s degree in Environmental Engineering in 2010 and Ph.D. in Material Physics and Chemistry with Professor Yan Xiang at Beihang University in 2015. Her graduate research focused on the development of biohybrid photoelectric devices and electronics. Dr. Rao began her postdoctoral research in neuroengineering and bioelectronics in Professor Polina Anikeeva’s lab at MIT in 2016. She has been a Simons Postdoctoral Fellow from 2016 to 2018 under the cosupervision of Professors Polina Anikeeva and Guoping Feng at MIT and developed the chemomagnetic technique with Simons projects. She is a recipient of NIH Pathway to Independence Award (K99/R00). Jingyi Qiu received her B.S. degree in Biological Science from Sichuan Agricultural University in 2015, and her Masters degree in Biomedical Engineering from the University of Houston in 2018. In 2020, she enrolled in the Biomedical Engineering Ph.D. program at the University of Massachusetts Amherst and joined Professor Siyuan Rao’s laboratory. Jingyi’s expertises are in biomarker development, pharmacokinetics, and protein engineering. Currently Jingyi is developing nanomaterial-based platforms for neurobiological system delivery. The authors thank K. Felix for her comments on our manuscript. S.R. is funded by NIH (K99MH120279). This article references 10 other publications.
更新日期：2021-05-28
Siyuan Rao is an Assistant Professor in the Biomedical Engineering Department at the University of Massachusetts Amherst and the principal investigator of the Neurobiological Interfaces Laboratory. She obtained her Bachelor’s degree in Environmental Engineering in 2010 and Ph.D. in Material Physics and Chemistry with Professor Yan Xiang at Beihang University in 2015. Her graduate research focused on the development of biohybrid photoelectric devices and electronics. Dr. Rao began her postdoctoral research in neuroengineering and bioelectronics in Professor Polina Anikeeva’s lab at MIT in 2016. She has been a Simons Postdoctoral Fellow from 2016 to 2018 under the cosupervision of Professors Polina Anikeeva and Guoping Feng at MIT and developed the chemomagnetic technique with Simons projects. She is a recipient of NIH Pathway to Independence Award (K99/R00). Jingyi Qiu received her B.S. degree in Biological Science from Sichuan Agricultural University in 2015, and her Masters degree in Biomedical Engineering from the University of Houston in 2018. In 2020, she enrolled in the Biomedical Engineering Ph.D. program at the University of Massachusetts Amherst and joined Professor Siyuan Rao’s laboratory. Jingyi’s expertises are in biomarker development, pharmacokinetics, and protein engineering. Currently Jingyi is developing nanomaterial-based platforms for neurobiological system delivery. The authors thank K. Felix for her comments on our manuscript. S.R. is funded by NIH (K99MH120279). This article references 10 other publications.
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