Objective

It is an exciting time in oncology nursing as new treatments are continually emerging to improve oncological outcomes for people affected by cancer. Immunotherapy is one such innovation in contemporary oncology practice, but the side effects of its treatment can be life threatening. Oncology nurses must be educated in the early identification of life-threatening side effects, and deliver evidence-based interventions to manage consequences of therapy such as, immune checkpoint inhibitor-related adrenal insufficiency.

Data Source

This article utilizes a case study to emphasize the need for early identification and interventions for clinical management of immunotherapy related adrenal insufficiency. A review of the current evidence is included to provide recommendations for oncology nurses who are involved in providing care for people affected by cancer receiving immunotherapy.

Implications for Nursing Practice: Oncology nurses are the frontline caregivers to assess, recognize, so that early intervention and treament can lead to optimal patient outcomes.

Conclusion

Adrenal insufficiency is a life-threatening condition that is difficult to diagnose but if recognized early, morbidity can be prevented, quality of life improved, treatment initiated and life saving immunotherapy treatment can safely continue. Oncology nurses play an active role in ensuring the safe administration of immunotherapy by recognizing this important immune related adverse event. I would like to give credit to Patricia Jakel, RN, MSN, UCLA CNS and Dr. Melissa Lechner, UCLA endocrinologist for their invaluable input in this article.

中文翻译：

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免疫检查点抑制剂相关的肾上腺功能不全

客观的

这是肿瘤护理的一个激动人心的时刻，因为不断出现新的治疗方法来改善受癌症影响的人的肿瘤治疗结果。免疫疗法是当代肿瘤学实践中的一项创新，但其治疗的副作用可能会危及生命。肿瘤科护士必须接受早期识别危及生命的副作用的教育，并提供循证干预措施来管理治疗后果，例如免疫检查点抑制剂相关的肾上腺功能不全。

数据源

本文利用一个案例研究来强调对免疫治疗相关的肾上腺功能不全的临床管理进行早期识别和干预的必要性。包括对当前证据的审查，以便为参与为接受免疫治疗的癌症患者提供护理的肿瘤科护士提供建议。

对护理实践的影响：肿瘤科护士是评估和识别的一线护理人员，以便早期干预和治疗可以带来最佳的患者结果。

结论

肾上腺功能不全是一种危及生命的疾病，难以诊断，但如果及早发现，可以预防发病率，提高生活质量，开始治疗，挽救生命的免疫疗法治疗可以安全地继续。肿瘤科护士通过识别这一重要的免疫相关不良事件，在确保免疫治疗的安全管理方面发挥着积极作用。我要感谢 Patricia Jakel、RN、MSN、UCLA CNS 和 Melissa Lechner 博士，UCLA 内分泌学家在本文中提供的宝贵意见。