TGF-β activates pericytes via induction of the epithelial-to-mesenchymal transition protein SLUG in glioblastoma,Neuropathology and Applied Neurobiology

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TGF-β activates pericytes via induction of the epithelial-to-mesenchymal transition protein SLUG in glioblastoma
Neuropathology and Applied Neurobiology ( IF 5 ) Pub Date : 2021-03-29 , DOI: 10.1111/nan.12714
Naita M Wirsik _{1,

2} , Jakob Ehlers _{3,

4} , Lisa Mäder _{1,

5} , Elena I Ilina _{1,

6,

7} , Anna-Eva Blank _{1,

8} , Anne Grote ₉ , Friedrich Feuerhake _{9,

10} , Peter Baumgarten _{1,

11} , Kavi Devraj _{1,

12} , Patrick N Harter _{1,

12,

13,

14} , Michel Mittelbronn _{1,

6,

7,

15,

16} , Ulrike Naumann ₃

Affiliation

Edinger Institute (Neurological Institute), Goethe University Hospital, Frankfurt/Main, Germany.
General-, Visceral- and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Laboratory of Molecular Neuro-Oncology, Department of Vascular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.
Department of Neurology, Klinikum Darmstadt, Darmstadt, Germany.
Luxembourg Centre of Neuropathology (LCNP), Luxembourg, Luxembourg.
Department of Oncology (DONC), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.
Pediatric Cardiology, University Hospital of Giessen, Gießen, Germany.
Institute for Pathology, Hannover Medical School, Hannover, Germany.
Institute for Neuropathology, University Clinic Freiburg, Freiburg, Germany.
Department of Neurosurgery, Goethe University, Frankfurt/Main, Germany.
German Cancer Consortium (DKTK), Heidelberg, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.
Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.
Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg.
National Center of Pathology (NCP), Laboratoire Nationale de Santé (LNS), Luxembourg, Luxembourg.

In primary central nervous system tumours, epithelial-to-mesenchymal transition (EMT) gene expression is associated with increased malignancy. However, it has also been shown that EMT factors in gliomas are almost exclusively expressed by glioma vessel-associated pericytes (GA-Peris). In this study, we aimed to identify the mechanism of EMT in GA-Peris and its impact on angiogenic processes.

中文翻译：

TGF-β通过诱导胶质母细胞瘤中的上皮间质转化蛋白SLUG激活周细胞

在原发性中枢神经系统肿瘤中，上皮间质转化 (EMT) 基因表达与恶性肿瘤增加有关。然而，也表明神经胶质瘤中的 EMT 因子几乎完全由神经胶质瘤血管相关周细胞 (GA-Peris) 表达。在这项研究中，我们旨在确定 GA-Peris 中 EMT 的机制及其对血管生成过程的影响。

更新日期：2021-03-29

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