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Development of a strategic approach for comprehensive detection of organophosphate pesticide metabolites in urine: Extrapolation of cadusafos and prothiofos metabolomics data of mice to humans
Journal of Occupational Health ( IF 3 ) Pub Date : 2021-03-29 , DOI: 10.1002/1348-9585.12218
Karin Nomasa 1 , Naoko Oya 1, 2 , Yuki Ito 1 , Takehito Terajima 3 , Takahiro Nishino 1 , Nayan Chandra Mohanto 1 , Hirotaka Sato 1 , Motohiro Tomizawa 3 , Michihiro Kamijima 1
Affiliation  

The comprehensive detection of environmental chemicals in biospecimens, an indispensable task in exposome research, is advancing. This study aimed to develop an exposomic approach to identify urinary metabolites of organophosphate (OP) pesticides, specifically cadusafos and prothiofos metabolites, as an example chemical group, using an original metabolome dataset generated from animal experiments.

中文翻译:

全面检测尿液中有机磷农药代谢物的战略方法的开发:cadusafos和prothiofos代谢组学数据对人类的外推

生物样本中环境化学物质的全面检测是暴露研究中必不可少的一项工作。这项研究的目的是使用一种动物实验产生的原始代谢组数据集,开发一种暴露组学方法来鉴定有机磷酸酯(OP)农药的尿代谢物,特别是cadusafos和prothiofos代谢物,作为示例化学组。
更新日期:2021-03-29
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