Introduction: Nonalcoholic fatty liver disease (NAFLD) is defined by the accumulation of triglycerides (TG). The body mass index (BMI) is associated with NAFLD. This large-scale cohort study was performed to evaluate and quantify the mediating effect of TG on the association between BMI and NAFLD. Methods: In total, 15,943 participants in the Kailuan Group were recruited between 2010 and 2014. The impact of TG on the association between BMI and NAFLD was determined through a mediation analysis. Results: BMI was an independent risk factor for incident NAFLD, with OR of 1.416 (95% CI 1.338–1.499) and 1.187 (95% CI 1.137–1.240) in the low-BMI and high-BMI groups, respectively (p #x3c; 0.001). The TG level was a risk factor for NAFLD in the high-BMI group, with an OR of 2.775 (95% CI 1.488–5.177; p = 0.001). Positive associations between BMI and the TG level remained in the 2 above mentioned groups after adjusting for confounders (β = 0.072 and 0.032; p #x3c; 0.001). The mediation analysis revealed that TG contributed to 26.050% of incident NAFLD in the high-BMI group (p = 0.01). Conclusion: A high BMI was an independent risk factor for incident NAFLD, and a high TG level was a risk factor in the high-BMI group (BMI ≥24). TG contributes about 25% to incident NAFLD in people with obesity.
Obes Facts

中文翻译：

---

甘油三酯介导体重指数和非酒精性脂肪肝：一项基于人群的研究

简介：非酒精性脂肪性肝病 (NAFLD) 是由甘油三酯 (TG) 的积聚定义的。体重指数 (BMI) 与 NAFLD 相关。这项大规模队列研究旨在评估和量化 TG 对 BMI 和 NAFLD 之间关联的中介作用。方法： 2010 年至 2014 年期间，开滦组共招募了 15,943 名参与者。通过中介分析确定 TG 对 BMI 和 NAFLD 之间关联的影响。结果： BMI 是发生 NAFLD 的独立危险因素，低 BMI 组和高 BMI 组的 OR 分别为 1.416（95% CI 1.338-1.499）和 1.187（95% CI 1.137-1.240）（ p#x3c; 0.001）。TG 水平是高 BMI 组 NAFLD 的危险因素，OR 为 2.775（95% CI 1.488–5.177；p = 0.001）。在调整混杂因素后，BMI 和 TG 水平之间的正相关仍然存在于上述 2 个组中（β = 0.072 和 0.032；p #x3c；0.001）。中介分析显示，在高 BMI 组中，TG 占 NAFLD 发生率的 26.050%（p = 0.01）。结论：高BMI是NAFLD发生的独立危险因素，高TG水平是高BMI组（BMI≥24）的危险因素。在肥胖人群中，TG 对 NAFLD 的发生贡献了约 25%。
肥胖事实