Allelic variants in the gene for apolipoprotein L1 (APOL1), found only in individuals of African ancestry, explain a majority of the excess risk of kidney disease in African Americans. However, a clear understanding how the disease-associated APOL1 variants cause kidney injury and the identity of environmental stressors that trigger the injury process have not been determined.

中文翻译：

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载脂蛋白L1和肾脏疾病易感性机制。

载脂蛋白 L1 (APOL1) 基因中的等位基因变异仅在非洲血统的个体中发现，这解释了非洲裔美国人患肾病风险过高的大部分原因。然而，尚未确定与疾病相关的 APOL1 变异如何导致肾损伤以及触发损伤过程的环境压力源的身份。