Over the past 5 years, four major randomized controlled trials were published informing our practice on the optimal timing for kidney replacement therapy (KRT) initiation in critically ill patients with acute kidney injury (AKI). In this review, we summarize the main findings of these trails and discuss the knowledge gaps that still need to be addressed.

中文翻译：

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急性肾损伤中肾脏替代治疗的开始时间。

在过去的 5 年中，发表了四项主要的随机对照试验，告知我们在急性肾损伤 (AKI) 危重患者中开始肾脏替代治疗 (KRT) 的最佳时机。在这篇综述中，我们总结了这些路径的主要发现，并讨论了仍然需要解决的知识差距。