Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. Although the overall incidence is less than 10 per 100,000 individuals, its poor prognosis and low survival rate make GBM a crucial public health issue. The main challenges for GBM treatment are related to tumor location and its complex and heterogeneous biology. In this sense, a broad range of nanoparticles with different sizes, architectures, and surface properties, have been engineered as brain drug delivery systems. Among them, lipid-based nanoparticles, such as liposomes, have been pointed out as promising materials to deliver antitumoral drugs to the central nervous system and thus, to improve brain drug targeting and therapeutic efficiency. Here, we describe the synthesis and general characteristics of lipid-based nanoparticles, as well as evidence in the past 5 years regarding their potential use to treat GBM.

胶质母细胞瘤 (GBM) 是成人中最常见和最具侵袭性的恶性脑肿瘤。虽然总发病率低于每 10 万人中 10 人，但其预后差和存活率低使 GBM 成为一个重要的公共卫生问题。GBM 治疗的主要挑战与肿瘤位置及其复杂和异质的生物学有关。从这个意义上说，具有不同尺寸、结构和表面特性的各种纳米颗粒已被设计为大脑药物输送系统。其中，脂质基纳米粒子，如脂质体，已被指出是将抗肿瘤药物输送到中枢神经系统，从而提高脑部药物靶向性和治疗效率的有前途的材料。在这里，我们描述了基于脂质的纳米粒子的合成和一般特性，