Background

Due to the importance of choosing the applicable dosimetry method in radionuclide therapy, the present study was conducted to investigate the efficiency of the implementation of Dose Point Kernel (DPK) for dose optimization of ¹⁷⁷Lu/⁹⁰Y Cocktail Radionuclides in internal Dosimetry.

Methods

In this study, simulations and calculations of DPK were performed using the GATE/GEANT4 Monte Carlo code. For specific liver dosimetry, the NCAT phantom and convolution algorithm-based Fast Fourier Transform method was used by MATLAB software.

Results

The self-dose of ¹⁷⁷Lu and ⁹⁰Y radionuclides in the liver of NCAT phantom were 1.1708E-13, and 4.8420E-11 (Gy/Bq), respectively, and the cross-dose of ¹⁷⁷Lu and ⁹⁰Y radionuclides out of the liver of NCAT phantom were 2.03615E-16, and 0.8422E-13 (Gy/Bq) respectively. Overall results showed that with an increase the value of ⁹⁰Y with quarter steps in a cocktail, the amount of the self-dose increase 1.5, 6, and 29 times respectively, and with an increase the value of ¹⁷⁷Lu in quarter step in a cocktail, the amount of the cross dose decrease 3, 15 and 68 percent respectively.

Conclusion

Generally, the present results indicate that the calculated DPK functions of ¹⁷⁷Lu and ⁹⁰Y cocktails can play an important role in choosing the best combination of radionuclide to optimize treatment planning in cocktail radionuclide therapy.

中文翻译：

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177Lu/90Y 混合放射性核素在内部剂量测定中剂量优化的剂量点核 (DPK) 实现

背景

由于在放射性核素治疗中选择适用的剂量学方法的重要性，本研究旨在调查剂量点核 (DPK)在内部剂量学中对¹⁷⁷ Lu/ ⁹⁰ Y 鸡尾酒放射性核素的剂量优化的实施效率。

方法

在本研究中，DPK 的模拟和计算是使用 GATE/GEANT4 蒙特卡罗代码进行的。对于特定的肝脏剂量测定，MATLAB 软件使用了基于 NCAT 幻像和卷积算法的快速傅立叶变换方法。

结果

NCAT 模型肝脏中¹⁷⁷ Lu 和⁹⁰ Y 放射性核素的自身剂量分别为 1.1708E-13 和 4.8420E-11 (Gy/Bq)，¹⁷⁷ Lu 和⁹⁰ Y 放射性核素的交叉剂量分别为NCAT 体模的肝脏分别为 2.03615E-16 和 0.8422E-13 (Gy/Bq)。总体结果表明，在鸡尾酒中，随着⁹⁰ Y值的增加，自我剂量分别增加了 1.5、6 和 29 倍，并且随着¹⁷⁷ Lu值的增加，鸡尾酒的四分之一步增加了鸡尾酒，交叉剂量的量分别减少了 3%、15% 和 68%。

结论

总的来说，目前的结果表明，¹⁷⁷ Lu 和⁹⁰ Y 鸡尾酒的计算 DPK 函数可以在选择放射性核素的最佳组合以优化鸡尾酒放射性核素治疗的治疗计划方面发挥重要作用。