Little is known about the relationship between psychomotor disturbance (PMD) and treatment outcome of psychotic depression. This study examined the association between PMD and subsequent remission and relapse of treated psychotic depression.

Two hundred and sixty-nine men and women aged 18–85 years with an episode of psychotic depression were treated with open-label sertraline plus olanzapine for up to 12 weeks. Participants who remained in remission or near-remission following an 8-week stabilization phase were eligible to participate in a 36-week randomized controlled trial (RCT) that compared the efficacy and tolerability of sertraline plus olanzapine (n = 64) with sertraline plus placebo (n = 62). PMD was measured with the psychiatrist-rated sign-based CORE at acute phase baseline and at RCT baseline. Spearman's correlations and logistic regression analyses were used to analyze the association between CORE total score at acute phase baseline and remission/near-remission and CORE total score at RCT baseline and relapse.

Higher CORE total score at acute phase baseline was associated with lower frequency of remission/near-remission. Higher CORE total score at RCT baseline was associated with higher frequency of relapse, in the RCT sample as a whole, as well as in each of the two randomized groups.

PMD is associated with poorer outcome of psychotic depression treated with sertraline plus olanzapine. Future research needs to examine the neurobiology of PMD in psychotic depression in relation to treatment outcome.

关于精神运动障碍 (PMD) 与精神病性抑郁症治疗结果之间的关系知之甚少。这项研究检查了 PMD 与治疗后的精神病性抑郁症的缓解和复发之间的关联。

269 名患有精神病性抑郁症的 18-85 岁男性和女性接受了开放标签舍曲林加奥氮平长达 12 周的治疗。在 8 周的稳定阶段后仍处于缓解或接近缓解状态的参与者有资格参加为期 36 周的随机对照试验 (RCT)，该试验比较了舍曲林加奥氮平（n = 64）与舍曲林加安慰剂的疗效和耐受性( ñ= 62）。PMD 是在急性期基线和 RCT 基线时用精神科医生评定的基于体征的 CORE 测量的。Spearman 相关性和逻辑回归分析用于分析急性期基线时的 CORE 总分与缓解/接近缓解以及 RCT 基线时的 CORE 总分与复发之间的关联。

急性期基线时较高的 CORE 总分与较低的缓解/接近缓解频率相关。在 RCT 基线时较高的 CORE 总分与较高的复发频率相关，无论是在整个 RCT 样本中，还是在两个随机分组中。

PMD 与使用舍曲林加奥氮平治疗的精神病性抑郁症的较差结果相关。未来的研究需要检查与治疗结果相关的精神病性抑郁症 PMD 的神经生物学。