This study examined the efficacy of attention bias modification training (ABMT) for the treatment of depression.

In this randomized clinical trial, 145 adults (77% female, 62% white) with at least moderate depression severity [i.e. self-reported Quick Inventory of Depressive Symptomatology (QIDS-SR) ⩾13] and a negative attention bias were randomized to active ABMT, sham ABMT, or assessments only. The training consisted of two in-clinic and three (brief) at-home ABMT sessions per week for 4 weeks (2224 training trials total). The pre-registered primary outcome was change in QIDS-SR. Secondary outcomes were the 17-item Hamilton Depression Rating Scale (HRSD) and anhedonic depression and anxious arousal from the Mood and Anxiety Symptom Questionnaire (MASQ). Primary and secondary outcomes were administered at baseline and four weekly assessments during ABMT.

Intent-to-treat analyses indicated that, relative to assessment-only, active ABMT significantly reduced QIDS-SR and HRSD scores by an additional 0.62 ± 0.23 (p = 0.008, d = −0.57) and 0.74 ± 0.31 (p = 0.021, d = −0.49) points per week. Similar results were observed for active v. sham ABMT: a greater symptom reduction of 0.44 ± 0.24 QIDS-SR (p = 0.067, d = −0.41) and 0.69 ± 0.32 HRSD (p = 0.033, d = −0.42) points per week. Sham ABMT did not significantly differ from the assessment-only condition. No significant differences were observed for the MASQ scales.

Depressed individuals with at least modest negative attentional bias benefitted from active ABMT.

本研究检验了注意力偏差修正训练 (ABMT) 治疗抑郁症的疗效。

在这项随机临床试验中，145 名成年人（77% 为女性，62% 为白人）至少有中度抑郁严重程度 [即自我报告的抑郁症状快速清单 (QIDS-SR) 13] 和负性注意力偏倚被随机分配到主动ABMT、假 ABMT 或仅评估。培训包括每周两次在诊所和三个（简短的）家庭 ABMT 课程，持续 4 周（总共 2224 次培训试验）。预登记的主要结果是 QIDS-SR 的变化。次要结果是 17 项汉密尔顿抑郁量表 (HRSD) 和来自情绪和焦虑症状问卷 (MASQ) 的快感缺失抑郁和焦虑唤醒。主要和次要结果在基线时进行，并在 ABMT 期间进行每周四次评估。

意向治疗分析表明，相对于仅评估，积极的 ABMT 显着降低了 QIDS-SR 和 HRSD 评分额外的 0.62 ± 0.23（p = 0.008，d = −0.57）和 0.74 ± 0.31（p = 0.021，d = −0.49) 点/周。积极与假ABMT观察到类似的结果：每周症状减少 0.44 ± 0.24 QIDS-SR（p = 0.067，d = -0.41）和 0.69 ± 0.32 HRSD（p = 0.033，d = -0.42）点. 假 ABMT 与仅评估条件没有显着差异。MASQ 量表未观察到显着差异。

至少有适度的负面注意偏见的抑郁个体受益于积极的 ABMT。