The Changkeng quartz vein tungsten deposit is located in the eastern part of the Helong ore field, Nanling region, South China. It has a proven WO₃ reserves of 9680 tons WO₃, and an average grade of 2.98%. It contains 28 ore-bearing quartz veins, and the mineralization stages are divided as follows: (I) quartz-wolframite-cassiterite-scheelite stage; (II) quartz-wolframite-scheelite-molybdenite-pyrite-sphalerite-galena-flourite stage; (III) quartz-calcite-flourite stage. The intrusion within the deposit is concealed, and comprising medium- and coarse-grained biotite monzogranite. Zircon grains from the Changkeng pluton have a U-Pb age of 156.7 ± 0.54 Ma (MSWD = 2.9). Cassiterite grains from stage I yield a weighted mean ²⁰⁶Pb/²³⁸U age of 156.1 ± 3.4 Ma (MSWD = 3.4). Molybdenite separates from stage II have a well-defined ¹⁸⁷Re/¹⁸⁷Os isochron age of 156.9 ± 2.0 Ma (MSWD = 0.77), with model ages ranging from 155.6 ± 2.5 to 157.5 ± 2.2 Ma. The zircon ε_Hf(t) values range from −14.1 to −11.1, and the Hf two-stage model ages range from 1.87 to 2.06 Ga, indicating a primary reworking of the Paleoproterozoic crust. The low rhenium contents (0.3238 to 8.763 μg/g) in molybdenite suggest that the ore-forming materials was derived from a crustal source. The age consistence between the intrusion and mineralization, together with the Hf and Re isotope signature, all indicate a close genetic link between magmatism and mineralization. The Changkeng deposit is an example of a Jurassic regional-scale tungsten-tin ore-forming event between 160 and 150 Ma in the Nanling region, South China.