Objectives

To investigate the relationship of spiritual well-being and quality of life (QOL) in patients undergoing treatment for non-small cell lung cancer (NSCLC) and to identify the role of four different symptoms (ie, appetite loss, dyspnea, pain, and fatigue) in mediating this relationship

Data Sources

A total of 132 consecutive patients undergoing chemotherapy, radiotherapy, or concurrent chemoradiotherapy for NSCLC from National University Hospital were examined. Symptoms were assessed using the symptom subscale of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-C30 (QLQ-C30). Spiritual well-being was assessed using the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being scale. Global QOL was assessed using the item on global health status from the European Organization for Research and Treatment of Cancer. Data of all self-reported surveys were analyzed using serial multiple mediation analysis.

Conclusion

Spiritual well-being directly affected QOL in patients undergoing treatment for NSCLC. In addition, a serial multiple mediation model showed causal relationships of spiritual well-being on appetite loss, appetite loss on dyspnea, dyspnea on pain, pain on fatigue, and fatigue on QOL.

Implications for Nursing Practice

: Providing integrated care that considers spiritual well-being may improve the QOL of patients undergoing treatment for NSCLC. Our findings emphasized the need to conduct routine assessments of spiritual well-being and symptoms when characterizing patient QOL.

中文翻译：

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接受非小细胞肺癌治疗的患者的精神健康、症状和生活质量的相互作用：一项横断面研究

目标

研究接受非小细胞肺癌 (NSCLC) 治疗的患者的精神健康和生活质量 (QOL) 的关系，并确定四种不同症状（即食欲减退、呼吸困难、疼痛和疲劳）在调解这种关系

数据源

共对 132 名来自国立大学医院的 NSCLC 接受化疗、放疗或同步放化疗的连续患者进行了检查。使用欧洲癌症研究和治疗组织 (EORTC) 生活质量问卷-C30 (QLQ-C30) 的症状分量表评估症状。使用慢性疾病治疗功能评估-精神健康量表评估精神健康。使用欧洲癌症研究和治疗组织的全球健康状况项目评估全球 QOL。所有自我报告调查的数据均使用串行多重中介分析进行分析。

结论

精神健康直接影响接受非小细胞肺癌治疗的患者的生活质量。此外，一系列多重中介模型显示精神健康与食欲减退、食欲减退呼吸困难、疼痛呼吸困难、疲劳疼痛和生活质量疲劳之间存在因果关系。

对护理实践的影响

：提供考虑精神健康的综合护理可能会改善接受 NSCLC 治疗的患者的 QOL。我们的研究结果强调了在表征患者 QOL 时对精神健康和症状进行常规评估的必要性。