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The role and mechanisms of polycomb repressive complex 2 on the regulation of osteogenic and neurogenic differentiation of stem cells
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-03-23 , DOI: 10.1111/cpr.13032
Yangyang Cao 1 , Le Li 2 , Zhipeng Fan 1, 3
Affiliation  

The stem cells differentiate into osteoblasts or neurocytes is the key process for treatment of bone‐ or neural tissue‐related diseases which is caused by ageing, fracture, injury, inflammation, etc Polycomb group complexes (PcGs), especially the polycomb repressive complex 2 (PRC2), act as pivotal epigenetic regulators by modifying key developmental regulatory genes during stem cells differentiation. In this review, we summarize the core subunits, the variants and the potential functions of PRC2. We also highlight the underlying mechanisms of PRC2 associated with the osteogenic and neurogenic differentiation of stem cells, including its interaction with non‐coding RNAs, histone acetyltransferases, histone demethylase, DNA methyltransferase and polycomb repressive complex 1. This review provided a substantial information of epigenetic regulation mediated by PRC2 which leads to the osteogenic and neurogenic differentiation of stem cells.

中文翻译:

聚梳抑制复合物2在调节干细胞成骨和神经分化中的作用和机制

干细胞分化为成骨细胞或神经细胞是治疗与骨或神经组织相关疾病的关键过程,这些疾病是由老化,骨折,损伤,炎症等引起的。Polycomb group complex(PcGs),尤其是polycomb repressive complex 2 PRC2)通过在干细胞分化过程中修饰关键的发育调控基因来充当关键的表观遗传调控因子。在这篇综述中,我们总结了PRC2的核心亚基,变异体和潜在功能。我们还着重介绍了PRC2与干细胞的成骨和神经发生分化相关的潜在机制,包括其与非编码RNA,组蛋白乙酰转移酶,组蛋白脱甲基酶,DNA甲基转移酶和多梳抑制复合物1的相互作用。由PRC2介导的调节,导致干细胞的成骨和神经发生分化。
更新日期:2021-05-02
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