Vascular smooth muscle cells (VSMC) switch to macrophage‐like cells after cholesterol loading, and this change may play an important role in atherogenesis. Muscleblind‐like splicing regulator 1 (MBNL1) is a well‐known splicing factor that has been implicated in many cellular processes. However, the role of MBNL1 in VSMC macrophage‐like transdifferentiation is largely unknown. In this study, we aim to characterize the role of MBNL1‐induced gene splicing during atherogenesis.

中文翻译：

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MBNL1对Abi1基因的RNA剪接有助于动脉粥样硬化形成过程中血管平滑肌细胞的巨噬细胞样表型调节

胆固醇加载后，血管平滑肌细胞（VSMC）转变为巨噬细胞样细胞，这种变化可能在动脉粥样硬化中起重要作用。类似于肌肉盲的剪接调节剂1（MBNL1）是一种众所周知的剪接因子，已牵涉到许多细胞过程中。但是，MBNL1在VSMC巨噬细胞样转分化中的作用尚不清楚。在这项研究中，我们旨在表征在动脉粥样硬化发生过程中MBNL1诱导的基因剪接的作用。