The objective of this review was to comprehensively evaluate the literature investigating associations between peripheral immune correlates and youth peer relationship dimensions. We aimed to identify potential aspects of peer relationships in childhood and adolescence that may be associated with immune profiles and to identify gaps in the field to provide suggestions for future research in this area. We conducted a systematic electronic search in health-related databases from the earliest records to December 2020. Search terms included domains related to youth, immune correlates, and peers. We summarized studies by the time between the peer measurement and the immune outcome. In the 17 included studies, associations between peer dimensions and immune outcomes varied substantially. Peer victimization in youth demonstrated the most consistent negative associations with immune health across development, including within 1 week of measurement, 1–3 years later, and 10 or more years later. This review indicated that that peer relationships during youth may have important associations with immune processes; however, there are several gaps in the literature regarding the operationalization of peer relationships, the timing of the immune measurement, and the type of immune outcome to be addressed by future research.

中文翻译：

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儿童和青少年同伴关系的外周免疫相关性：系统评价

本综述的目的是全面评估研究外周免疫相关性与青年同伴关系维度之间关联的文献。我们旨在确定可能与免疫特征相关的儿童和青少年同伴关系的潜在方面，并确定该领域的差距，为该领域的未来研究提供建议。从最早的记录到 2020 年 12 月，我们在健康相关数据库中进行了系统的电子搜索。搜索词包括与青年、免疫相关者和同龄人相关的领域。我们通过同伴测量和免疫结果之间的时间总结了研究。在纳入的 17 项研究中，同伴维度和免疫结果之间的关联差异很大。青年同伴受害与免疫健康在整个发育过程中表现出最一致的负面关联，包括在测量的 1 周内、1 至 3 年后以及 10 年或更长时间后。这项审查表明，青年时期的同伴关系可能与免疫过程有重要关联；然而，关于同伴关系的操作化、免疫测量的时间安排以及未来研究需要解决的免疫结果类型，文献中存在一些空白。