Background

Low sleep quality, cardiac autonomic dysfunction and poor quality of life are some of the most prevalent symptoms in people with Multiple Sclerosis (MS). In addition to the progression of the disease, these symptoms are aggravated by physical inactivity. Therefore, home confinement due to COVID-19 pandemic restrictions could further worsen these symptoms. This study aims to analyze the effect of home confinement on objective and subjective sleep quality, cardiac autonomic control based on heart rate variability (HRV), and health-related quality of life in people with MS.

Methods

Actigraphic and subjective sleep quality (Karolinska Sleep Diary, KSD), HRV (Polar-H7), and quality of life (Multiple Sclerosis Quality of Life-54) were measured before and after 2 months of home confinement in 17 people with MS (7:10 men/women; age: 43.41±10.88 years; body mass index: 24.87±3.31 kg/m²; Expanded Disability Status Scale: 2.85±1.34 a.u.).

Results

Actigraphic sleep quality (sleep efficiency: ES=1.27, p = 0.01, sleep time: ES=0.81, p = 0.01) and subjective sleep quality (sleep quality: ES=-0.34, p = 0.05), sleep comfort: ES=0.60; p = 0.03, ease of falling asleep: ES=0.70; p = 0.01, ease of waking up: ES=0.87, p<0.01, and having enough sleep: ES=0.87, p<0.01) significantly decreased after home confinement. No differences were observed in HRV or quality of life variables (p ≥ 0.13).

Conclusions

Home confinement has worsened the sleep quality, but not in cardiac autonomic control or quality of life, in people with MS. These data highlight the importance of implementing home physical training programs in this population when situations similar to home confinement occur, thus minimizing the negative effects of physical inactivity and their associated comorbidities.

中文翻译：

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COVID-19 居家隔离对多发性硬化症患者睡眠监测和心脏自主神经功能的影响：一项前瞻性队列研究✰,✰✰

背景

睡眠质量差、心脏自主神经功能障碍和生活质量差是多发性硬化症 (MS) 患者最普遍的一些症状。除了疾病的进展外，这些症状还会因缺乏身体活动而加重。因此，由于 COVID-19 大流行限制而在家隔离可能会进一步恶化这些症状。本研究旨在分析居家隔离对 MS 患者的客观和主观睡眠质量、基于心率变异性 (HRV) 的心脏自主控制以及健康相关生活质量的影响。

方法

在 17 名 MS 患者 (7 ：10 名男性/女性；年龄：43.41±10.88 岁；体重指数：24.87±3.31 kg/m ²；扩展残疾状况量表：2.85±1.34 au)。

结果

活动记录睡眠质量（睡眠效率：ES=1.27，p  = 0.01，睡眠时间：ES=0.81，p  = 0.01）和主观睡眠质量（睡眠质量：ES=-0.34，p  = 0.05），睡眠舒适度：ES=0.60 ; p  = 0.03，入睡难易度：ES=0.70；p  = 0.01，起床容易度：ES=0.87，p <0.01，睡眠充足：ES=0.87，p <0.01）居家隔离后显着下降。在 HRV 或生活质量变量方面未观察到差异 ( p  ≥ 0.13)。

结论

居家隔离恶化了 MS 患者的睡眠质量，但并未影响心脏自主神经控制或生活质量。这些数据强调了在发生类似于居家隔离的情况时，在这一人群中实施家庭体育锻炼计划的重要性，从而最大限度地减少缺乏身体活动及其相关合并症的负面影响。