The design of multifunctional agents became a pivotal task for the development of personalized medicine. In this study, we investigated the potential applicability of mesoporous silica decorated with gold nanoparticles (MS-Au NPs) for effective X-ray attenuation in computed tomography (CT) and as a potential vehicle for drug delivery. The physicochemical properties and X-ray attenuation efficiency of prepared MS-Au NPs were systematically studied using a range of characterization techniques and clinical CT correspondingly. CT analysis revealed that prepared MS-Au NPs exhibit high X-ray attenuation efficiency $\sim$9.8 HU/mM (Hounsfield Units per mM of Au) as compared to other perspective metal-based nanoparticles reported in the literature. An improved X-ray attenuation efficiency can be attributed to the presence of a large amount of Au nanoparticles in a confined volume unit.

多功能代理的设计已成为个性化医学发展的关键任务。在这项研究中，我们调查了用金纳米颗粒（MS-Au NPs）装饰的中孔二氧化硅对于计算机断层扫描（CT）中有效X射线衰减以及作为药物输送的潜在载体的潜在适用性。相应地使用一系列表征技术和临床CT系统研究了制备的MS-Au NP的理化性质和X射线衰减效率。CT分析表明，制备的MS-Au NP具有较高的X射线衰减效率$〜$9.8 hu / mM（每mM Au的Hounsfield单位），与文献中报道的其他透视金属基纳米颗粒相比。改善的X射线衰减效率可归因于在封闭的体积单元中存在大量的Au纳米颗粒。