Abstract

A series of novel oxo-spiro chromene Schiff’s bases were synthesized by condensing 2,7-diamino-2'-oxospiro[chromene-4,3'-indoline]-3-carbonitrile, and series of aromatic aldehydes. Spectrochemical techniques have corroborated the formation of desired products. Derivatives were screened in vitro for antibacterial and anticancer activities. Molecular docking analysis was also performed to predict the possible mode of action of these derivatives. The docking analysis ascertained that these derivatives regulate the antimicrobial potential via inhibition of DNA gyrase and anticancer potential via inhibition of CDK 6. Among all the synthesized compounds, Nitro derivatives have exhibited eminent anticancer and antibacterial activities.

中文翻译：

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某些新型Oxo-Spiro Chromene Schiff碱的合成，分子对接，体外抗细菌和抗癌活性

摘要

通过缩合2,7-二氨基-2'-氧螺并[chromene-4,3'-二氢吲哚] -3-腈和一系列芳香醛，合成了一系列新型的氧-螺亚铬基席夫碱。光谱化学技术证实了所需产物的形成。在体外筛选衍生物的抗菌和抗癌活性。还进行了分子对接分析以预测这些衍生物的可能作用方式。对接分析确定这些衍生物通过抑制DNA促旋酶调节抗微生物能力，并通过抑制CDK 6调节抗癌能力。在所有合成的化合物中，硝基衍生物均表现出显着的抗癌和抗菌活性。