Background/aims This study aimed to predict the possibility of steroid-induced ocular hypertension (OHT) after intravitreal dexamethasone (DEX) implantation and to identify a proper safety zone for such injections. Methods A cross-sectional observational study was conducted and included 908 patient eyes that underwent DEX implant injection due to various retinal diseases. Intraocular pressure (IOP) was measured before injection, at 1 week, and at 1, 2, 3, 6 and 12 months thereafter. Eyes of enrolled patients were divided into the OHT and normal IOP groups. Univariable logistic regression analysis was used to assess significant associations between steroid-induced OHT and covariates; significant and previously reported significant variables were analysed with a multivariable model, and predictive nomograms were developed. Results Age, sex, axial length, glaucomatous eye, neovascular glaucoma, secondary glaucoma, uveitis history, hypertension, depression, diabetes mellitus and a history of previous laser-assisted in-situ keratomileusis or laser-assisted subepithelial keratectomy were significantly related to steroid-induced OHT (p<0.05). The calibration plot revealed good prediction under a predicted value of 0.4. Cut-off values for 80%, 86%, 91%, 95% and 98% sensitivity and specificity were offered for the safety zone after intravitreal DEX implantation. Conclusion We developed two nomograms to predict a safety zone for intravitreal DEX implantation. These can be used to identify individuals who may be safely prescribed steroid treatments and for whom extra caution should be exercised. Data are available upon reasonable request. The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

中文翻译：

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预测玻璃体腔内地塞米松植入引起的类固醇性高眼压症的安全区

背景/目的 本研究旨在预测玻璃体内地塞米松 (DEX) 植入后类固醇诱发的高眼压 (OHT) 的可能性，并确定此类注射的适当安全区。方法 进行了一项横断面观察研究，包括 908 只因各种视网膜疾病而接受 DEX 植入物注射的患者眼睛。在注射前、1 周以及之后的 1、2、3、6 和 12 个月测量眼压 (IOP)。入组患者的眼睛分为OHT组和正常IOP组。单变量逻辑回归分析用于评估类固醇诱导的 OHT 和协变量之间的显着关联；使用多变量模型分析了重要变量和先前报告的重要变量，并开发了预测列线图。结果年龄、性别、眼轴长度、青光眼、新生血管性青光眼、继发性青光眼、葡萄膜炎史、高血压、抑郁症、糖尿病和既往激光辅助原位角膜磨镶术或激光辅助上皮下角膜切除术史与类固醇诱导的 OHT 显着相关（p< 0.05)。校准图在 0.4 的预测值下显示出良好的预测。玻璃体内 DEX 植入后安全区的敏感性和特异性分别为 80%、86%、91%、95% 和 98%。结论 我们开发了两个列线图来预测玻璃体内 DEX 植入的安全区。这些可用于识别可以安全地进行类固醇治疗的个体以及应格外小心的个体。可根据合理要求提供数据。