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Immunosuppressive effect of mesenchymal stem cells on lung and gut CD8+ T cells in lipopolysaccharide‐induced acute lung injury in mice
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-03-19 , DOI: 10.1111/cpr.13028
Yanping Xu 1, 2 , Jiaqi Zhu 1, 2 , Bing Feng 1, 2 , Feiyan Lin 1, 2 , Jiahang Zhou 1, 2 , Jingqi Liu 1, 2 , Xiaowei Shi 1 , Xuan Lu 1, 2 , Qiaoling Pan 1, 2 , Jiong Yu 1, 2 , Ying Zhang 1, 2 , Lanjuan Li 1, 2 , Hongcui Cao 1, 2, 3
Affiliation  

Acute lung injury (ALI) not only affects pulmonary function but also leads to intestinal dysfunction, which in turn contributes to ALI. Mesenchymal stem cell (MSC) transplantation can be a potential strategy in the treatment of ALI. However, the mechanisms of synergistic regulatory effects by MSCs on the lung and intestine in ALI need more in‐depth study.

中文翻译:

间充质干细胞对脂多糖诱导的急性肺损伤小鼠肺和肠道CD8 + T细胞的免疫抑制作用

急性肺损伤(ALI)不仅会影响肺功能,还会导致肠道功能障碍,进而导致ALI。间充质干细胞(MSC)移植可能是治疗ALI的潜在策略。但是,MSC对ALI肺和肠的协同调节作用的机制尚需更深入的研究。
更新日期:2021-05-02
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