Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD,Psychiatry Research: Neuroimaging

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Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD
Psychiatry Research: Neuroimaging ( IF 2.3 ) Pub Date : 2021-03-20 , DOI: 10.1016/j.pscychresns.2021.111282
Wenhao Jiang ₁ , Kelly Rootes-Murdy ₂ , Kuaikuai Duan ₃ , Gido Schoenmacker ₄ , Pieter J Hoekstra ₅ , Catharina A Hartman ₅ , Jaap Oosterlaan ₆ , Dirk Heslenfeld ₇ , Barbara Franke ₄ , Emma Sprooten ₈ , Jan Buitelaar ₉ , Alejandro Arias-Vasquez ₄ , Jingyu Liu ₁₀ , Jessica A Turner ₁₁

Affiliation

Department of Psychology, Georgia State University, United States; Department of Psychosomatics and Psychiatry, Zhongda Hospital, Institute of Psychosomatics, Medical School, Southeast University, Nanjing, China.
Department of Psychology, Georgia State University, United States.
School of Electrical and Computer Engineering, Georgia Institute of Technology, USA.
Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands.
Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands; Vrije Universiteit, Clinical Neuropsychology section, Van der Boechortstraat 7, 1081 BT Amsterdam, Netherlands.
Vrije Universiteit, Clinical Neuropsychology section, Van der Boechortstraat 7, 1081 BT Amsterdam, Netherlands.
Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, USA; Department of Computer Science, Georgia State University, USA.
Department of Psychology, Georgia State University, United States; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, USA; Neuroscience Institute, Georgia State University, USA.

A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

中文翻译：

多基因效应对青少年和成人多动症症状维度的差异

很大一部分患有注意力缺陷/多动障碍 (ADHD) 的人表现出持续到成年期。青少年与成人多动症的遗传和神经相关性仍然很差。我们调查了同一个 ADHD 样本（来自 NeuroIMAGE 和 IMpACT 队列的 462 名青少年和 422 名成人）中与先前确定的灰质 (GM) 模式、神经认知和症状发现相关的 ADHD 多基因风险评分 (PRS)。ADHD PRS 对青少年多动和冲动症状、成人多动症状有显着影响，但对 GM 体积成分没有显着影响。建议青少年和成人对个体 ADHD 症状有明显的 PRS 效应。

更新日期：2021-03-27

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