We use three-dimensional simulations to study the fluid–solid interactions between a highly-deflective biomimetic valve and a viscous fluid within a microfluidic channel, so as to guide the effective design of a biomimetic micropump. We study the steady state and dynamic behavior of the valve and fluid in response to applied fluid pressure gradients using a steady pressure drop and a trapezoidal pressure gradient waveform, respectively. We use dimensionless parameters to characterize the effect of various physical parameters on pumping performance. We determine the range of parameters in which valves can be designed to provide microfluidic pumping that is independent of the period of oscillation of pressure gradients driving the flow. Our findings guide the effective design of such a biomimetic microvalve for harnessing physiological motion to passively provide pumping in an implantable biosensor.

我们使用三维模拟来研究高偏转仿生阀和微流体通道内的粘性流体之间的流体-固体相互作用，从而指导仿生微型泵的有效设计。我们分别使用稳态压力降和梯形压力梯度波形来研究阀和流体响应于施加的流体压力梯度的稳态和动态行为。我们使用无量纲参数来表征各种物理参数对泵送性能的影响。我们确定了可以设计阀以提供微流体泵送的参数范围，该参数与驱动流的压力梯度的振荡周期无关。