Persons with current or past major depressive disorder (MDD) vs those without have higher smoking rates. The nicotine metabolite ratio (NMR) represents variation in the rate of nicotine metabolism and has been associated with smoking behaviors and response to tobacco treatments. We compared NMR between smokers with current or past MDD (MDD+) vs smokers without MDD (MDD−). We also assessed correlates of NMR and compared withdrawal and craving between MDD+ and MDD− smokers.

中文翻译：

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比较患有当前或过去重度抑郁症的吸烟者的尼古丁代谢率

目前或过去患有重度抑郁症 (MDD) 的人与没有患重度抑郁症的人相比，吸烟率更高。尼古丁代谢物比率 (NMR) 代表尼古丁代谢率的变化，并且与吸烟行为和对烟草治疗的反应有关。我们比较了患有当前或过去 MDD (MDD+) 的吸烟者与没有 MDD (MDD-) 的吸烟者之间的 NMR。我们还评估了 NMR 的相关性，并比较了 MDD+ 和 MDD- 吸烟者之间的戒断和渴望。