Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) are highly influenced by changes in the microbiota and of microbiota-derived metabolites, including short chain fatty acids, bile acids, and tryptophan derivatives. This review will discuss the effects of microbiota-derived metabolites on neuroinflammation driven by central nervous system-resident cells and peripheral immune cells, and their influence on outcomes of EAE and MS.

中文翻译：

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微生物群衍生代谢物对多发性硬化症神经炎症的直接和间接影响

多发性硬化症 (MS) 和实验性自身免疫性脑脊髓炎 (EAE) 受到微生物群和微生物群衍生代谢物（包括短链脂肪酸、胆汁酸和色氨酸衍生物）变化的高度影响。本综述将讨论微生物群衍生代谢物对中枢神经系统驻留细胞和外周免疫细胞驱动的神经炎症的影响，以及它们对 EAE 和 MS 结局的影响。