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The impact of population-wide rapid antigen testing on SARS-CoV-2 prevalence in Slovakia
Science ( IF 56.9 ) Pub Date : 2021-05-07 , DOI: 10.1126/science.abf9648
Martin Pavelka 1, 2, 3 , Kevin Van-Zandvoort 4, 5 , Sam Abbott 4, 5 , Katharine Sherratt 4, 5 , Marek Majdan 6 , Pavol Jarčuška 7 , Marek Krajčí 1 , Stefan Flasche 4, 5 , Sebastian Funk 4, 5 , ,
Affiliation  

Slovakia conducted multiple rounds of population-wide rapid antigen testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2020, combined with a period of additional contact restrictions. Observed prevalence decreased by 58% (95% confidence interval: 57 to 58%) within 1 week in the 45 counties that were subject to two rounds of mass testing, an estimate that remained robust when adjusting for multiple potential confounders. Adjusting for epidemic growth of 4.4% (1.1 to 6.9%) per day preceding the mass testing campaign, the estimated decrease in prevalence compared with a scenario of unmitigated growth was 70% (67 to 73%). Modeling indicated that this decrease could not be explained solely by infection control measures but required the addition of the isolation and quarantine of household members of those testing positive.



中文翻译:

人群中快速抗原检测对斯洛伐克SARS-CoV-2患病率的影响

斯洛伐克于2020年底对严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)进行了多轮人群范围的快速抗原检测,并进行了一段时间的接触限制。在接受两轮大规模测试的45个县中,观察到的患病率在1周内下降了58%(95%置信区间:57到58%),这一估计值在调整多个潜在混杂因素时仍然很可靠。在进行大规模测试之前,根据流行病每天增长4.4%(1.1至6.9%)进行调整后,与未缓解增长情况相比,估计的患病率下降了70%(67至73%)。模型表明,这种下降不能仅通过感染控制措施来解释,而是需要增加测试阳性的家庭成员的隔离和检疫。

更新日期:2021-05-07
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